The centrosome
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چکیده
منابع مشابه
The centrosome
All cells are polar. This is particularly evident in eukaryotic cells, where an organized cytoskeleton is used to differentiate parts of the cell. Microtubules — an important part of this cytoskeleton — are especially well suited to playing a part in cell polarity because of their own intrinsic polarity. And the centrosome, the unique organelle that organizes microtubules into useful arrays, is...
متن کاملCentrosome Biology: The Ins and Outs of Centrosome Assembly
As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
متن کاملCentrosome-associated NDR kinase regulates centrosome duplication.
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
متن کاملThe centrosome–Golgi apparatus nexus
A shared feature among all microtubule (MT)-dependent processes is the requirement for MTs to be organized in arrays of defined geometry. At a fundamental level, this is achieved by precisely controlling the timing and localization of the nucleation events that give rise to new MTs. To this end, MT nucleation is restricted to specific subcellular sites called MT-organizing centres. The primary ...
متن کاملMonoclonal antibody against the centrosome.
A monoclonal antibody, MPM-13, raised against mitotic HeLa cell extracts recognized a perinuclear area in interphase cells and spindle poles in mitotic cells of human, mouse, Chinese hamster and sea urchin. On immunoblots MPM-13 recognized a major protein band at 43 X 10(3) Mr and a variable minor band at 56 X 10(3) Mr in both mitotic and interphase HeLa cells. These antigens were detectable in...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1999
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(99)80201-2